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Morley D Hollenberg Selected Research

PAR-2 Receptor

1/2022Giardia duodenalis cysteine proteases cleave proteinase-activated receptor-2 to regulate intestinal goblet cell mucin gene expression.
11/2021Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77).
1/2020Proteinase-Mediated Macrophage Signaling in Psoriatic Arthritis.
1/2019Protease-Activated Receptor 2 Agonist as Adjuvant: Augmenting Development of Protective Memory CD8 T Cell Responses Induced by Influenza Virosomes.
11/2018Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia.
11/2017Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling.
7/2016Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5.
7/2012Interleukin-17- and protease-activated receptor 2-mediated production of CXCL1 and CXCL8 modulated by cyclosporine A, vitamin D3 and glucocorticoids in human keratinocytes.
11/2011Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.
12/2010Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients.
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Morley D Hollenberg Research Topics

Disease

52Inflammation (Inflammations)
11/2022 - 08/2002
23Neoplasms (Cancer)
01/2022 - 01/2005
7Infections
04/2022 - 02/2002
7Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
05/2021 - 11/2002
7Colitis
05/2021 - 09/2003
6Neuroinflammatory Diseases
10/2019 - 06/2005
5Edema (Dropsy)
01/2021 - 09/2007
5Pain (Aches)
01/2021 - 10/2017
4Type 2 Diabetes Mellitus (MODY)
01/2022 - 01/2011
4Carcinogenesis
04/2012 - 06/2002
3Hyperglycemia
11/2021 - 01/2011
3Neoplasm Metastasis (Metastasis)
01/2021 - 01/2012
3Rheumatoid Arthritis
01/2020 - 03/2006
3Pancreatic Neoplasms (Pancreatic Cancer)
08/2019 - 07/2016
3Lung Injury
01/2019 - 06/2005
3Asthma (Bronchial Asthma)
12/2018 - 05/2006
3Pneumonia (Pneumonitis)
11/2018 - 03/2003
3Multiple Sclerosis
01/2018 - 03/2003
3Adenocarcinoma
11/2017 - 07/2016
3Colonic Neoplasms (Colon Cancer)
07/2012 - 11/2011
2COVID-19
04/2022 - 01/2022
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022 - 10/2007
2Malaria
01/2022 - 01/2016
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2022 - 03/2010
2Insulin Resistance
01/2022 - 01/2021
2Mitochondrial Diseases (Mitochondrial Disease)
11/2021 - 10/2019
2Crohn Disease (Crohn's Disease)
05/2021 - 11/2002
2Hyperalgesia
01/2021 - 09/2007
2Psoriatic Arthritis
01/2021 - 01/2020
2Osteoarthritis
01/2020 - 01/2018
2Neurocognitive Disorders (Clerambault Syndrome)
10/2019 - 11/2015
2Human Influenza (Influenza)
01/2019 - 05/2008
2Hypersensitivity (Allergy)
01/2019 - 10/2017
2Prostatic Neoplasms (Prostate Cancer)
01/2018 - 09/2014
2Hemorrhage
01/2017 - 06/2009
2Sepsis (Septicemia)
12/2015 - 10/2007
2Body Weight (Weight, Body)
08/2014 - 12/2008
2Lentivirus Infections
11/2011 - 09/2009
2Radiation Injuries (Radiation Sickness)
07/2010 - 11/2003
2Encephalitis (Encephalitis, Rasmussen)
06/2010 - 03/2003
2HIV Infections (HIV Infection)
06/2010 - 06/2005
2Hepatocellular Carcinoma (Hepatoma)
09/2009 - 06/2007
2Cerebral Hemorrhage
06/2009 - 10/2006
1Atherosclerosis
11/2022
1Giardiasis
01/2022

Drug/Important Bio-Agent (IBA)

51Peptide Hydrolases (Proteases)FDA Link
11/2022 - 06/2002
30Proteinase-Activated ReceptorsIBA
05/2021 - 08/2002
16Serine Proteases (Serine Protease)IBA
11/2022 - 03/2003
16PAR-2 ReceptorIBA
01/2022 - 11/2003
15ThrombinFDA Link
05/2021 - 08/2002
14CytokinesIBA
04/2022 - 06/2005
14G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
12/2018 - 03/2003
11Peptides (Polypeptides)IBA
01/2019 - 08/2002
10Kallikreins (Kallikrein)IBA
11/2022 - 06/2008
9Proteins (Proteins, Gene)FDA Link
04/2022 - 06/2005
9CalciumIBA
01/2022 - 04/2010
8Messenger RNA (mRNA)IBA
04/2022 - 02/2002
6TrypsinIBA
12/2018 - 11/2002
5Metformin (Glucophage)FDA LinkGeneric
01/2022 - 10/2019
4EnzymesIBA
04/2022 - 06/2008
4Insulin (Novolin)FDA Link
01/2022 - 03/2010
4Tryptases (Tryptase)IBA
11/2018 - 11/2002
4PAR-1 ReceptorIBA
11/2015 - 03/2003
3Mitogen-Activated Protein KinasesIBA
01/2022 - 04/2010
3Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2021 - 12/2004
3LigandsIBA
01/2018 - 10/2004
3Transforming Growth Factors (Transforming Growth Factor)IBA
11/2017 - 12/2013
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2017 - 06/2005
3Biomarkers (Surrogate Marker)IBA
09/2014 - 04/2010
3NeuropeptidesIBA
04/2013 - 09/2003
3Pancreatic Elastase (Elastase)IBA
07/2011 - 03/2003
3Thrombin Receptors (Thrombin Receptor)IBA
06/2009 - 04/2006
2Pharmaceutical PreparationsIBA
01/2022 - 01/2010
2Reactive Oxygen Species (Oxygen Radicals)IBA
11/2021 - 01/2018
2Sodium-Glucose Transport ProteinsIBA
07/2020 - 10/2019
2Phosphotransferases (Kinase)IBA
10/2019 - 04/2012
2ErbB Receptors (EGF Receptor)IBA
10/2019 - 12/2013
2Protein Kinase CIBA
10/2019 - 03/2010
2Opioid Analgesics (Opioids)IBA
01/2019 - 10/2018
2Analgesics (Analgesic Drugs)IBA
01/2019 - 10/2018
2beta-Arrestin 1IBA
12/2018 - 10/2012
2MucinsIBA
12/2018 - 10/2012
2AllergensIBA
12/2018 - 09/2007
2Aquaporins (Water Channels)IBA
10/2018 - 10/2017
2LipidsIBA
01/2018 - 08/2014
2Ion Channels (Ion Channel)IBA
10/2017 - 10/2016
2Prostate-Specific Antigen (Semenogelase)IBA
09/2014 - 06/2008
2GTP-Binding Proteins (G-Protein)IBA
09/2014 - 02/2005
2CollagenIBA
12/2013 - 04/2006
2Sulfonic AcidsIBA
01/2013 - 11/2004
2ProstaglandinsIBA
07/2012 - 12/2004
2Cathepsin GIBA
07/2011 - 03/2003
2Matrix Metalloproteinases (MMPs)IBA
06/2009 - 04/2006
2Capsaicin (Zostrix)FDA Link
09/2007 - 09/2003
2Biological ProductsIBA
02/2005 - 11/2003
1Apolipoproteins E (ApoE)IBA
11/2022
1Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA
11/2022
1VaccinesIBA
04/2022
1Cysteine Proteases (Cysteine Protease)IBA
01/2022

Therapy/Procedure

7Therapeutics
01/2016 - 03/2006